Much will be made about the events before the game where sections of the Liverpool fan base attacked the City team bus in an embarrassing attempt to intimidate the players, but Pep Guardiola will have to take the blame for this one with his decisions tactically for City.
With the second leg coming up on Tuesday, Guardiola is trying to keep his players fresh for a potential comeback.
"In this room, I think there is nobody, except the guy talking to you, who believes we can go through", the Spaniard said after City's 3-0 loss at Liverpool in the first leg of the Champions League quarterfinals.
He acknowledged before Wednesday's game that City's style plays right into the hands of Liverpool, but said he would not budge in his beliefs.
JOSE MOURINHO, Manchester United manager, on his targeted outcome from today's Manchester derby. "We have just a few days between each game". It is so complicated because we are going to play a top, top team. We will have a training session and we'll speak with the docs and see what's the best team. We have one eye on Tuesday though.
"And, of course, now it is not done, so the people say, "you're going to win".
"It's the first time we've lost two games in a row this season and now we have to recover, try again, come back to basics and win games". It happened many times.
United won the title by the widest margin when they took it by 18 points in 1999-2000 but that record could also fall to City, who, with 88 goals scored, have their sights set on Chelsea's 103 netted in 2009-2010.
"When you analyse the game, it was good, so I can not expect 30 minutes and the opponent doesn't do absolutely anything". Now happiness is aside, there's no way to continue happy with a result of this and a game like that, speaking personally.
For all the inevitability of City's eventual confirmation of their third Premier League title, there was genuine disappointment and frustration from their supporters that it was not achieved with United in opposition.
The second coming from another horrendous mistake where Alex-Oxlade Chamberlain was allowed all the space in the world by City's defence to rocket home a stunning shot to double the lead, City's defenders were too slow off the mark to close him down.