Having overcome AC Milan in the last 16 they will hope to set one foot in the semi-finals by securing a lead over their Russian opponents in the home leg.
Since joining Arsene Wenger's side in January, Mkhitaryan has made 11 appearances, scoring two goals and assisting a further six strikes.
Although Ramsey's early opener was quickly cancelled out by a delightful Aleksandr Golovin free-kick, Arsenal rarely looked in danger of failing to win, as the brilliant Mesut Ozil soon turned on the style to win a penalty that Lacazette fired home.
Ramsey hit the post as he too could not earn a memorable hat trick before Akinfeev did well to keep out Welbeck's close-range effort. Danny Welbeck, however, went off injured and was thought to be a doubt, but reports suggest that he could be available and start from the bench as could Jack Wilshere who had just recovered from a knee injury before the Stoke game.
And, even though the fans' frustrations are abundantly evident, Arsene Wenger is confident that they will come out in force for the game against CSKA Moscow, particularly with so much at stake for the club. But, as such, David Ospina has been the preferred choice in cup games this season, and should keep his place.
Cristiano Ronaldo's superb overhead kick for Real Madrid against Juventus in the Champions League followed Alex Oxlade-Chamberlain's rocket shot for Liverpool against Manchester City.
A rampant home side them extended their lead in sumptuous fashion again though Ramsey.
Five minutes later Ramsey produced a bit of magic, volleying a pass from Ozil with his heel beyond goalkeeper Igor Akinfeev.
Ozil was again the creator when Lacazette also grabbed a double by shooting into the far corner for his first goal from open play in almost three months.
After a good move in the ninth minute, Hector Bellerin collected the ball on the right before sending in a low cross for Ramsey to score.
For those that like statistics, CSKA have scored 102 goals in 62 matches at an average of 1.65 goals per game.
The competition offers Arsenal their only realistic chance of securing Champions League football for next season and on this evidence they will take some beating, as they swept their visitors aside with consummate ease on Thursday.
Almost 12 years later, the Gunners will be looking to avenge that result in this evening's Europa League quarter-final clash.