The bus was returning to Texas from Orlando after a band competition at Disney World.
"They're a very successful band", said Kramer, adding that the second busload of students was due back at Channelview later on Tuesday.
A video of the crash shot in the early morning showed a bus on its side in a grassy aqueduct or ravine as rescuers with flashlights scoured the area. The interstate was closed in both directions as the injured were flown to hospitals and a free-standing emergency room in rural Baldwin County, said Chris Elliott, a Baldwin County commissioner who helped at the county emergency management center following the crash. "We are extremely grateful for the first responders, hospital employees and volunteers from churches and schools in Alabama and Florida that have stepped up to help our students and comfort them through this hard situation".
This photo provided by Jesus Tejada shows first responders searching around a bus that plunged into a ravine, Tuesday, March 13, 2018 on Interstate 10, Loxley, Ala.
The band members were on their way home from a spring break trip to Disney World at the time. "Thank God they were alive but (they) had to take them on (a) helicopter", he said in an interview conducted by instant messages.
No one was injured or killed in the other three crashes.
The other bus careened off the interstate early Tuesday in Alabama and down a ravine before toppling onto its side.
Josh Torres said his 17-year-old sister, Bianca Torres, was sitting at the rear of the bus when the impact of the wreck tossed her forward several rows.
An investigation into the cause of the crash is underway.
More than 40 passengers on the bus were taken to 10 hospitals across southern Alabama and the Florida Panhandle to be evaluated, but the total number of injuries wasn't yet known. He said he is keeping the driver's family in his prayers.
Authorities in Alabama say a charter tour bus carrying students on a school trip from Houston, Texas, has plunged into a ravine, with multiple injuries reported.
Authorities hope to reopen the highway by noon (1 p.m. ET), said Alabama State Trooper Capt. John Malone.