Despite Liverpool winning the home fixture against the Saints 3-0 in November, previous league meetings between the two have always proved to be tricky - and Southampton will be looking to widen the gap between them and the relegation zone with a huge win.
Liverpool boosted their hopes of Champions League football against next year by beating Southampton 2-0 at St Mary's.
The African forward started the weekend one goal adrift of the Premier League's leading goal-scorer Harry Kane before the England worldwide netted the victor in the north London derby.
Lovren has started on 18 occasions in the Premier League this season and the Croatian worldwide played alongside van Dijk against Spurs in the dramatic 2-2 draw at Anfield.
Southampton versus Liverpool games are like a derby nowadays so the fans and players should be well up for this one.
After Salah played the ball into Firmino's feet 5 yards outside Southampton's box, the South American proceeded to slide his teammate through on goal with the most sumptuous of flicked passes with his instep, with Salah going on to finish in typically-cool style.
"Last season, little by little, Jack was playing more in the second part of the season and that is more or less the same now". Liverpool have only lost one match (away to Swansea) in their last 17 (11 wins, five draws) Premier League games.
Claude Puel, Pellegrino's predecessor, was dismissed after a solitary season and there were cries from the home support of "you don't know what you're doing" when Shane Long replaced James Ward-Prowse. Here's to an emphatic three points.