Cameroon were the continent's surprise champions in Gabon earlier this year, but their limitations were exposed during the Confederations Cup in Russian Federation and completely laid bare in Uyo as Nigeria ran riot.
Team captain, Mikel Obi, and forward, Odion Ighalo, who are plying their trade in the Chinese Super League, showed superb understanding between themselves upfront as they inspired a first half silencing of the Lions.
Also in the game, Super Eagles Team B captain and FC Ifeanyi Ubah goalkeeper, Ikechukwu Ezenwa, who came in as last minute replacement for injured Daniel Akpeyi, also gave a good account of himself in the game as he maintained a clean sheet against all odds.
Mikel Obi will go on to double the lead in the 42nd minute from a corner-kick.
The Indomitable Lions came out strong from the start of the first and second half, and put up a lot of efforts but just couldn't stop the Eagles from flying.
The Chelsea man had started a counter attacking move, picking the ball from the front of the Nigerian box and taking out two players before feeding Moses Simon who fed him back.
Nigeria still maintained their maximum nine points from three games in the qualifiers having defeated Zambia, Algeria, and now Cameroon.
Nigeria travel to Youande for the fourth group game against Cameroon which will be played on Monday, September 4.