Sharapova became the first woman into the third round at the US Open by using 12 aces to help set aside a poor start and coming back to beat Timea Babos of Hungary 6-7 (4), 6-4, 6-1 on Wednesday in Arthur Ashe Stadium.
Five-time Grand Slam champion Sharapova closed her remarks to a supportive crowd by saying that behind her fancy dress and sparkly crystals, "This girl has a lot of grit and she's not going anywhere".
Vandeweghe beat fellow countrywomen Alison Riske 2-6, 6-3, 6-4 elsewhere today while eighth seed Svetlana Kuznetsova of Russian Federation survived three match points before defeating Czech Republic's Marketa Vondrousova 4-6, 6-4, 7-6 (2).
Less than 24 hours following her emotional three-set win over Simona Halep, which ended the Romanian's chances of becoming world number one post-tournament, the Russian backed up that victory with another gritty three-set win, confirming herself as one of the dark horses of the tournament.
Timea Babos celebrates after winning a point during her second-round match against Maria Sharapova at the 2017 U.S. Open.
In a very open section of the draw also featuring Sharapova, American Sloane Stephens continued her fine comeback from a year out with a foot injury by upsetting 11th seed Dominika Cibulkova.
"I always felt I could play at this level, so I'm really proud of myself for getting here", Kenin said.
"I've had a diabolical year at the Slams", Kyrgios said. The U.S. Tennis Association did grant a wild card to Sharapova, who was once ranked No. 1 but is now 146th.
In the men's part, Zverev, whose five ATP titles this year include a win over Roger Federer in this month's Montreal final, fell to 61st-ranked Croatian Borna Coric 3-6, 7-5, 7-6 (1), 7-6 (4).
Dominic Thiem didn't need long to finish off his first-round victory once play resumed.
While Stephens and Makarova provided the drama, past US Open champions Venus Williams and Svetlana Kuznetsova also advanced.
Time to play catch-up at the U.S. Open.
The victory seems to instill the faith in Sharapova that she is back to her best.
Plenty of big names were in action and are still to come on Wednesday due to rain ruining play on every court but the main one on Tuesday.
The weather shouldn't be a problem Wednesday, with sunny skies and almost flawless conditions.
The 30-year-old Russian became the first player into the third round where she will face Russian-born USA teen wildcard Sofia Kenin.
Russia's Daria Kasatkina has meanwhile beaten China's qualifier Wang Qiang 6-7 (7-9), 6-2, 6-3 in the first round of US Open and will next face Christina McHale, who has triumphed over 19-seeded Anastasia Pavlyuchenkova.