The pop superstar closed out her "One Love Manchester" benefit concert on Sunday (June 4) by performing a rousing version of the track, which was first made famous by Judy Garland in The Wizard of Oz.
Days before the show, she turned up unannounced at a Manchester-area hospital to visit young girls wounded in the attack.
Grande and Miley Cyrus ensured there wasn't a tear left unshed during their duet of "Don't Dream It's Over".
The concert, which featured Coldplay, Pharrell Williams, Justin Bieber and The Black Eyed Peas, was broadcast around the world. A song that, unfortunately, hasn't lost any of its meaning over the last 14 years. More than $13 million had been raised by Sunday night for the We Love Manchester Emergency Fund, the British Red Cross told the Associated Press.
Ahead of the show tonight, which will take place in Paris, France, she showed gratitude. The concert was confirmed last week on a Twitter post by the singer.
HollywoodLifers, are you going to buy Ariana's benefit single?
Our hearts go out to everyone affected by the Manchester attack.
Tipping says: "We can't let them stop us".
Concert-goers in Manchester showed the city's spirit by defiantly belting out "Don't Look Back In Anger" on the tram ride home from the One Love concert. Grande revealed that ahead of the concert, she met with Campbell's mother.